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concomitant vs concurrent chemotherapy

15,000 peer-reviewed journals. – Springer Journals. 2005; 23 (16s):7014. What is known about tumour proliferation rates to choose between accelerated fraction or hyperfraction? Look in other contemporaneous works to see whether that idea was common then. Thanks for helping us catch any problems with articles on DeepDyve. Median follow-up was 23.5 months (2-79 months). Carboplatin plus 5-fluorouracil (carbo-5FU) is another accepted treatment option with a different toxicity profile. Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly. Enjoy affordable access to Historic cancer treatment protocols often required patients to undergo chemotherapy and radiation separately. Komaki R, Seiferheld W, Curran W, et al. Address reprint requests to Bin S. Teh, MD, Baylor College of Medicine, One Baylor Plaza, 165B Houston, TX 77030. Median survival in the chemo-radiotherapy arm was 11.4 months vs 14 in the induction arm (P=0.154), with one-year survival of 48% and 54%, respectively. This study was designed to evaluate the tolerability and therapeutic activity of paclitaxel and carboplatin combination therapy followed by radical thoracic radiotherapy with a concomitant boost technique with concurrent weekly paclitaxel in good performance status of patients with stage IIIA and IIIB non-small cell lung cancer. PURPOSE: Early-stage nasopharyngeal carcinoma (NPC) continues to carry a failure rate of 15% to 30% when treated with radiotherapy alone; the benefit of concomitant radiotherapy and chemotherapy (CCRT) in early-stage NPC is unclear. The addition of concurrent chemotherapy to RT in patients with high-risk major SGCs did not offer an advantage in OS. Adjective (-) Existing or created in the same period of time. Median survival in the chemo-radiotherapy arm was 11.4 months vs 14 in the induction arm (P=0.154), with one-year survival of 48% and 54%, respectively. 1 Primary sites include the parotid, submandibular, and sublingual glands. Concurrent chemotherapy and radiation provide for the systemic treatment of patients with micrometastatic and macrometastatic disease and simultaneously enhance local therapy in the form of chemosensitized external beam radiotherapy (EBRT). Acute confluent mucositis (Radiation Therapy Oncology [RTOG] grade 3) developed in 50% of patients, but there was no severe long-term treatment-related toxicity. A total of 70 Gy was delivered over 6 weeks. Require these words, in this exact order. Seven hundred sixteen patients were included in this trial. Adjuvant therapy, also known as adjunct therapy, and adjuvant care, is therapy that is given in addition to the primary or initial therapy to maximize its effectiveness. Google Scholar To subscribe to email alerts, please log in first, or sign up for a DeepDyve account if you don’t already have one. vs concurrent chemoradiotherapy with TPF in patients with locally . However, around one-third of the patients cannot complete cisplatin because of toxicity. 1995 Kragujevac - Jeremic I PMID 7844608-- "Randomized trial of hyperfractionated radiation therapy with or without concurrent chemotherapy for stage III non-small-cell lung cancer." DeepDyve's default query mode: search by keyword or DOI. However, no direct evidence so far demonstrated better efficacy of sequential use of chemotherapy and endocrine therapy over concurrent. Treatment-related toxicity was acceptable with 50% of patients developing acute confluent mucositis. We therefore performed a retrospective ana-lysis in a mono-institutional group with newly diagnosed The surgeries and complex treatment regimens used in cancer therapy have led the term to be used mainly to describe adjuvant cancer treatments. 7 Integration of a third chemotherapy agent to the induction and concurrent chemoradiotherapy regimen may improve distant and local disease control, respectively. that matters to you. The median and 1-yr progression-free survival rates were 9.0 mo and 27.8%, respectively. Adjuvant hormonal therapy is given after prostate removal in prostate cancer, but there are concerns that the side effects , in particular the cardiovascular ones, may outweigh the risk of recurrence. Despite the use of C-CRT with cisplatin, many patients continue to fail in the pelvis (20–25%) and at distant sites (10–20%) ( 7 - 10 ), even the Cochrane meta-analysis ( 11 ) has shown decreasing advantage of C-CRT over radiotherapy (RT) alone as the stage increases. The optimal sequencing of chemotherapy and radiotherapy after breast surgery was largely studied but remains controversial. Search Concomitant chemoradiotherapy versus acceleration of radiotherapy with or without concomitant chemotherapy in locally advanced head and neck carcinoma (GORTEC 99-02): an open-label phase 3 randomised trial. We are evaluating the feasibility of the concomitant use of chemotherapy retrospectively. Do not surround your terms in double-quotes ("") in this field. Oral, Ethem; Aydiner, Adnan; Eralp, Yeşim; Topuz, Erkan, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png, http://www.deepdyve.com/lp/springer-journals/induction-and-concurrent-chemotherapy-with-concomitant-boost-3F0OSOh77l. Concomitant chemoradiotherapy has led to promising results when combination chemotherapy regimens were used in the phase II setting. Radiation Therapy Oncology Group, Eastern Cooperative Oncology Group, and Southwest Oncology Group, Hyperfractionated radiation therapy with or without concurrent low-dose daily carboplatin/etoposide for stage III non-small-cell lung cancer: a randomized study, Jeremic, B; Shibamoto, Y; Acimovic, L; Milisavljevic, S, Phase III study of concurrent versus sequential thoracic radiotherapy in combination with mitomycin, vindesine, and cisplatin in unresectable stage III non-small cell lung cancer, Long term benefit is observed in a phase III comparison of sequential vs. concurrent chemo-radiation for patients with unresected stage III NSCLC: RTOG 9410, Sequential versus concurrent chemo-radiation (RT-CT) in locally advanced non small cell lung cancer (NSCLC): a French randomized phase III trial of GLOT-GFPC (NPC 95-01 study), Concurrent versus sequential chemoradiotherapy with cisplatin and vinorelbine in locally advanced non-small cell lung cancer: a randomized study, Optimizing chemoradiation therapy approaches to unresectable stage III non-small cell lung cancer, Programming of radiotherapy in the treatment of non-small cell lung cancer-a way to advance care, Inoperable non-small cell lung cancer: radiation with or without chemotherapy, Thoracic radiation therapy alone compared with combined chemoradiotherapy for locally unresectable non- small-cell lung cancer. Leibel S et al (1987)2 RTOG group IIIB-IVA RT alone vs RT+ Misonidazole Median survival in control arm 1.9 yrs. A randomised trial of neoadjuvant vs concomitant chemotherapy vs radiotherapy alone in the treatment of stage IV head and neck squamous cell carcinoma. Submitting a report will send us an email through our customer support system. Concurrent chemotherapy for locally advanced head and neck cancer results in an absolute survival benefit of 6.5% at 5 years when compared with radiation alone. This approach has been used at the University of Texas M. D. Anderson Cancer Center in selected patients with sarcoma over the past decade. The main end point is the event free survival. The concurrent chemotherapy consisted Conclusions: Long-term results of this schedule are encouraging However. However, around one-third of the patients cannot complete cisplatin because of toxicity. (Jeremic B, J Clin Oncol. After a median follow-up of 6.7 years (range, 4.3-9 years), we decided to prospectively evaluate the late effects of these 2 strategies. Concomitant radiotherapy and chemotherapy for early-stage nasopharyngeal carcinoma. 1995 Feb;13(2):452-8.) concurrent ifosfamide was 10.2 g/m2. In … Copyright © 2000 by W.B. 169 pts. Background: Chemoradiotherapy (CRT) including three cycles of cisplatin is considered the standard of care for locally advanced head and neck squamous cell carcinoma (LA-HNSCC). The use of induction chemotherapy has been explored as a strategy to address distant treatment failures. Read from thousands of the leading scholarly journals from SpringerNature, Wiley-Blackwell, Oxford University Press and more. The median and 1-yr overall-survival rates were 24.9 mo and 63.8%, respectively. Bourhis J, Sire C, Graff P, et al. This is a randomized, multicenter, phase III trial comparing induction chemotherapy with Docetaxel, Cisplatin and 5-Fluorouracil (TPF) followed by concurrent chemoradiotherapy (Arm A) to concurrent chemoradiotherapy alone (Arm B), in nasopharyngeal cancers staged as T2b, T3, T4 and/or with lymph node involvement (≥ N1. Concomitant or concurrent systemic cancer therapy Concomitant or concurrent systemic cancer therapy refers to administering medical treatments at the same time as other therapies, such as radiation. Purpose: In 1996, a multicenter randomized study was initiated that compared sequential vs. concurrent adjuvant chemotherapy (CT) with radiation therapy (RT) after breast-conserving surgery (ARCOSEIN study). Published. Concomitant drugs in drug abuse. Materials and Methods: Forty-eight patients were treated with combined chemoradiotherapy between the years of 1990 and 1995. As adjectives the difference between concurrent and concomitant is that concurrent is happening at the same time; simultaneous while concomitant is accompanying; conjoined; attending; concurrent. We'll do our best to fix them. Concurrent chemotherapy is medication provided alongside radiation therapy for cancer patients. CHART Steering Comittee, A randomized phase I/II trial of hyperfractionated radiation therapy with total doses of 60.0 Gy to 79.2 Gy: possible survival benefit with greater than or equal to 69.6 Gy in favorable patients with Radiation Therapy Oncology Group stage III non-small-cell lung carcinoma: report of Radiation Therapy Oncology Group 83-11, Cisplatin-based chemotherapy (CT) in patients with locally advanced non-small-cell lung cancer (NSCLC): late analysis of a French randomized trial, Improved survival in stage III non-small-cell lung cancer: seven-year follow-up of Cancer and Leukemia Group B (CALGB) 84-33 trial, Dillman, RO; Herndon, J; Seagren, SL; Eaton, WL; Green, MR, Final results of phase III trial in regionally advanced, unresectable non-small-cell lung cancer. tumeur classbe T3b-4 ou de 65 & 80 % en cas de T2-3a Therapeutic strategies for muscle invasive bladder cancer are et le contrble locorkgional est excellent : proche de currently evolving. Radio-chimiothérapie concomitante dans les cancers ... have shown a limited but significant improvement of survival with induction chemotherapy, though local control remained poor in these studies as well as in small-cell lung cancer treated with chemotherapy and late radiotherapy. Journal Article. The NSCLC Collaborative Group performed a meta-analysis of randomized trials directly comparing concomitant versus sequential radiochemotherapy. Conventional vs concomitant boost radiotherapy with concurrent cisplatin in advanced head and neck cancer Sushil Dashrath Meshram, Krishna M Kamble, Ashok K Diwan, Vijay K Mohobia Department of Radiation Therapy and Oncology, Government Medical College and Hospital, Nagpur, Maharashtra, India The role of combined chemoradiation, Experience with dose escalating using CHARTWEL (continuous, hyperfractionated, accelerated radiotherapy weekend less) in non-small-cell lung cancer, A Radiation Therapy Oncology Group (RTOG) phase III radnomized study to compare hyperfractionation and two variants of accelerated fractionation to standard fractionation radiotherapy for head and neck squamous cell carcinomas: first report of RTOG 9003, Twice weekly paclitaxel and radiation for stage III non-small-cell lung cancer, Preliminary analysis of a phase II study of paclitaxel and CHART in locally advanced non-small cell lung cancer, Paclitaxel and simultaneous radiation in the treatment of stage III A/B non-small-cell lung cancer, Induction and concurrent chemotherapy with concomitant boost radiotherapy in non-small cell lung cancer. Eur Arch Otorhinolarygol 1992; 249:211–215. During radiation treatment, paclitaxel (60 mg/m2) was given as a 1-h infusion once weekly for 5 wk. Copyright © 2000 W.B. Concurrent delivery of cisplatin-based chemotherapy with TRT confers a long-term survival benefit compared with the sequential delivery of these therapies. shielding and concomitant high-dose rate intracavitary brachytherapy with 192-iridium remote after loading system for 6 Gy to point A of the Manchester method). The optimal integration of chemotherapy with radiotherapy (either conventional or altered fractionation) in the management of advanced unresectable head and neck cancers is still unclear. Overall survival at 2 years, 3 years, and 5 years were 58.7%, 52.8%, and 42.4%, respectively. Unlimited access to over18 million full-text articles. Despite promising results in the earlier studies, treatment intensification by adding induction or consolidation chemotherapy or targeted therapy to concomitant radiochemotherapy have not yet demonstrated any survival benefit over concurrent radiochemotherapy alone. There was no severe long-term treatment-related toxicity. Overall response rate to the treatment was 65.2%. Concurrent chemotherapy for locally advanced head and neck cancer results in an absolute survival benefit of 6.5% at 5 years when compared with radiation alone. We are evaluating the feasibility of the concomitant use of chemotherapy retrospectively. [Abstract] Int J Radiat Oncol Biol Phys 48 (3 suppl): A-5, 113, 2000. Published. PURPOSE: Early-stage nasopharyngeal carcinoma (NPC) continues to carry a failure rate of 15% to 30% when treated with radiotherapy alone; the benefit of concomitant radiotherapy and chemotherapy (CCRT) in early-stage NPC is unclear. Purpose: The previous individual patient data meta-analyses of chemotherapy in locally advanced non-small-cell lung cancer (NSCLC) showed that adding sequential or concomitant chemotherapy to radiotherapy improved survival. Concurrent chemoradiotherapy (C-CRT) with cisplatin based chemotherapy is the current standard of treatment (4-6). We use cookies to help provide and enhance our service and tailor content and ads. for Misonidazole arm. Aprks cystectomie, le taux de survie g Concurrent chemotherapy and radiotherapy for bladder 5 ans varie de 15 ZI 30 % pour les patients atteints de cancer: an overview. Cisplatin-etoposide regimen related toxicity is high, weekly regimens have been investigating. Patients with newly diagnosed inoperable non-small cell lung cancer received paclitaxel (100 mg/m2) as a 1-h infusion on d 1,8,15,28,35, and 42. In addition, concomitant chemoradiotherapy has been shown to be superior to induction chemotherapy in direct comparison. Finally, accelerated radiotherapy has been shown to lead to improved locoregional control and survival in one randomized study. Journal Article. §Otorhinolaryngology, Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX. Purpose: For patients with advanced head and neck cancer, various combined chemoradiotherapy regimens have been used to improve local control. A “concomitant boost” external beam radiotherapy approach was used with twice-daily treatment delivered during the last 2 weeks. (10) In the present work, we measured the inactivation of methionine synthase and the concurrent homocysteine export rate of two murine and four human cell lines during nitrous oxide exposure. Phase III study of concurrent chemotherapy and radiotherapy (CT/RT) vs CT/RT followed by surgical resection for stage IIIA (pN2) non-small cell lung cancer (NSCLC): outcomes update of North American Intergroup 0139 (RTOG 9309) (Abstract) Proc Am Soc Clin Oncol. They were placed on your computer when you launched this website. Select data courtesy of the U.S. National Library of Medicine. Median survival in complete responders has not been reached. Our experience suggests that concurrent chemotherapy and concomitant boost radiotherapy approaches appear promising. Radiotherapy commenced on d 49 and was delivered with accelerated fractionation with concomitant boost at 1.8 Gy/fraction/d, 5 d/week and 1.5 Gy/fraction/d to a boost field as a second daily treatment for the last 10 treatment days to 60 Gy/35 fractions/5 wk. Sequential vs. concurrent chemoradiation for stage III non-small cell lung cancer: randomized phase III trial RTOG 9410 However, no direct evidence so far demonstrated better efficacy of sequential use of chemotherapy and endocrine therapy over concurrent. No major late toxicity was seen. The patients were randomly assigned (by draw of lots) either of two groups; group I, the 0600 hour cisplatin administration and group II, the 1800 hour cisplatin administration group. Chemotherapy: All the patients were to receive concomitant cisplatin in dose of 30 mg/m 2 i.v. The optimal sequencing of chemotherapy and radiotherapy after breast surgery was largely studied but remains controversial. The CALGB group compared induction chemotherapy with two carboplatin and taxol cycles, followed by concomitant chemo-radiotherapy, vs concomitant chemo-radiotherapy alone . No significant dose-response relationship was found in terms of LRC. Email through our customer support system a third chemotherapy agent to the induction and chemoradiotherapy..., Belderbos JSA, Senan S, et al efficacy and safety of different concurrent chemotherapy Conclusions... In complete responders has not been reached catch any problems with articles on DeepDyve 35! 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In direct comparison further chest radiation after 20 Gy of a third chemotherapy agent the... Different toxicity profile:452-8. to prospectively evaluate the late effects of these two.... An article, log in first, or sign up for a DeepDyve account if you don ’ t have...: A-5, 113, 2000 citation format or use the link below download. Jsa, Senan S, et al and neck cancer, various combined chemoradiotherapy between the years of 1990 1995. Randomized trials directly comparing concomitant versus sequential radiochemotherapy account if you don ’ t have. Arm 1.9 yrs desired citation format or use the link below to download a file for. 42.4 %, 52.8 %, respectively in one place toxicities during induction ;... Improve your online experience RT+ Misonidazole median survival in complete responders has not been reached rectal refused. Total of 70 Gy was delivered more frequently for the sequential delivery of cisplatin-based chemotherapy with TRT confers a survival. Of breast cancer patients, 3 years, we decided to prospectively evaluate the late effects of these therapies affordable. Chemotherapy to RT concomitant vs concurrent chemotherapy patients with advanced head and neck squamous cell carcinoma of the patients can complete. §Otorhinolaryngology, Veterans Affairs Medical Center and Baylor College of Medicine, one Baylor Plaza, Houston... ) 2005 ; 17:148-52 online access to over 18 million full-text articles from more than 15,000 peer-reviewed.... Weekly for 5 wk ( 1987 ) 2 RTOG group IIIB-IVA RT alone vs RT+ Misonidazole median in! Desired citation format or use the link below to download a file formatted for EndNote http //www.deepdyve.com/lp/springer-journals/induction-and-concurrent-chemotherapy-with-concomitant-boost-3F0OSOh77l... And survival in complete responders has not been reached, Wiley-Blackwell, Oxford University Press more... 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